Abstract
Myocardial infarction (MI) is the main cause of heart failure and has a high prevalence and mortality and a great impact on social life. Naringin (Nar) and hesperidin (Hes) are citrus flavonoids, with powerful biological properties. The present study aimed to show the ameliorative effect of naringin and hesperidin and their combinations on improvement MI induced experimentally. Fifty rats were divided into five groups (ten rats each) as follow: Group 1: Healthy control group, Group 2: cardiac dysfunction (CD) induced group by adriamycin (ADR), Group 3: (CD + Nar) induced rats treated orally with naringin, Group 4: (CD + Hes) induced rats treated orally with hesperidin, Group 5: (CD +Nar+ Hes) induced group were treated orally with combination of naringin and hesperidin. Biochemical results revealed significant elevation of markers in groups treated with naringin, hesperidin and their combinations. Our results showed a significant increase in ox-LDL and MDA accompanied by a decrease in SOD in the CD-induced group. Combinations of treatment with naringin and hesperidin showed great improvement effects in all biochemical markers under investigation. The biochemical aspects have also been confirmed by histological findings. In conclusion: outcomes of the present study confirmed that treatment by either naringin, hesperidin or their combinations of naringin and hesperidin have a promising effective rate in ameliorating CD-induced experimentally.