Abstract
Diabetes mellitus is a significant risk factor for major adverse cardiovascular events and all-cause mortality. It is essential to control blood glucose levels, but a combination of controlled blood glucose and cardioprotective effect, mortality, and morbidity secondary to diabetes would be significantly reduced. Sodium-glucose coTransporter 2 inhibitor provides great diabetic control in addition to protection against cardiovascular events, with or without increased cardiovascular risks. This narrative review aims to assess the efficacy and safety of SGLT2i in preventing cardiovascular consequences among patients with diabetes mellitus type-2. A search in the PubMed database was performed for relevant articles using the following Mesh words: Sodium-glucose cotransporter 2 inhibitor, an SGLT2 inhibitor, Cardiovascular protection, Cardiovascular events, myocardial infarction. SGLT-2 inhibitors were found to provide cardiovascular protection and decreased all-cause of death in addition to reasonable glycemic control compared to placebo. Several rare adverse effects were reported, but generally, all of them were affordable and well-tolerated. Further trials are recommended to establish SGLT-2 inhibitors concerning the risk of amputations.