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Catalyst-Free Regioselective [3+2] Cycloadditions of alpha,beta-unsaturated N-arylnitrones with Alkenes to Access Functionalized Isoxazolidines: A DFT Study
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Catalyst-Free Regioselective [3+2] Cycloadditions of alpha,beta-unsaturated N-arylnitrones with Alkenes to Access Functionalized Isoxazolidines: A DFT Study

Arnab Ghosh, Manoj V. Mane, Haridas B. Rode, Siddappa A. Patil, Balasubramanian Sridhar and Ramesh B. Dateer
Chemistry, an Asian journal, Vol.15(6), pp.899-903
16/03/2020
DOI: https://doi.org/10.1002/asia.201901754
PMID: 32056350

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
The catalyst-free regioselective [3+2]-cycloaddition of alpha,beta-unsaturated N-arylnitrones with alkenes are developed. The series of synthetically important functionalized isoxazolidines are prepared in good to excellent yields by step economic pathway under ligand and transition-metal-free conditions. The regioselective cycloaddition pathway supported by control experiment and computational study.

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