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Catalytic Reductive Dehydration of Tertiary Amides to Enamines under Hydrosilylation Conditions
Journal article   Peer reviewed

Catalytic Reductive Dehydration of Tertiary Amides to Enamines under Hydrosilylation Conditions

Alexey Volkov, Fredrik Tinnis and Hans Adolfsson
Organic letters, Vol.16(3), pp.680-683
07/02/2014
DOI: https://doi.org/10.1021/ol403302g
PMID: 24451007

Abstract

Chemical Sciences Kemi Natural Sciences Naturvetenskap Organic Chemistry Organisk kemi
Tertiary amides are efficiently reduced to their corresponding enamines under hydrosilylation conditions, using a transition-metal-free catalytic protocol based on t-BuOK (5 mol %) and (MeO)(3)SiH or (EtO)(3)SiH as the reducing agent. The enamines were formed with high selectivity in good-to-excellent yields.

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