Abstract
The novel benzonaphthyridinedione derivative, chaetominedione, has significant inhibitory activity toward p56
lck
tyrosine kinase (93.6% enzyme inhibition at 200
μg/mL).
A marine fungal isolate, identified as
Chaetomium sp., was cultivated and found to produce a novel benzonaphthyridinedione derivative, chaetominedione (
1). In addition to the known fungal metabolites, 2-furancarboxylic acid (
2) and 5-(hydroxymethyl)-2-furancarboxylic acid (
3) were obtained. The structures of all the compounds were determined based on extensive spectroscopic measurements (1D and 2D NMR, MS, UV, and IR). The total extract and compound
1 had significant inhibitory activity toward p56
lck
tyrosine kinase (18.7% and 93.6% enzyme inhibition at 200
μg/mL, respectively).