Abstract
This study aimed to a rapid, eco-friendly and low-cost method for green synthesis of pigment mediated silver nanoparticles by Penicillium vinaceum AUMC 9402 (Pp-AgNPs) as an alternative to chemical procedures. Pp-AgNPs were subjected to microscopic and spectrophotometric analysis to determine its shape and size as TEM, UV-Visible Spectrophotometer, XRD, FTIR and DLS. The TEM analysis has revealed the spherical shape of Pp-AgNPs with size ranged between 8.2 and 14.9nm with the mean of 10.6nm. Thermal stability of Pp-AgNPs was also studied by TGA and DSC analysis which revealed high thermal stability of theses nanoparticles. Moreover, Pp-AgNPs have been evaluated for their effect on the growth of some +ve and -ve bacterial strains as Staphylococcus aureus ATCC 6538, Bacillus subtilis NCTC 10400, Pseudomonas aeruginosa ATCC-10145 and Escherichia coli ATCC 8739. Results revealedthat Pp-AgNPs significantly have inhibitory effect on the tested bacteria. Additionally, the antitumor effect of Pp-AgNPs was also studied and the results revealed that these particles can be used as a promising antitumor agent.