Abstract
Herein, an efficient two-step process to synthesise a quinazoline derivative is described. First, an intermediate ( 3 ) was prepared from 5-methylanthranilic acid ( 1 ) and 4-fluorophenylisothiocyanate ( 2 ). Next, intermediate ( 3 ) reacted with sulfur alkylation using isopropyl bromide ( 4 ). The obtained compound, 3(4-Fluoro-phenyl)-2-isopropylsulfanyl-6-methyl-3H-quinazolin-4-one (QD 5 ), was characterized using several spectral analytical methods, such as Raman, NMR and FTIR, and DFT calculations were performed. QD 5 's antibacterial performance was evaluated; it demonstrated interesting activity against several bacterial strains. Docking studies indicated that there was conventional intermolecular hydrogen bonding between the active sites of the target enzymes and the docked molecules. (c) 2022 Elsevier B.V. All rights reserved.