Abstract
A simple and conventional spectrophotometric method is developed for quantitative analysis of fluoxetine. The method is based on the charge transfer 1: 1 complex formation of fluoxetine hydrochloride with electron acceptors: picric acid, dinitrobenzene, p-nitrobenzoic acid, 2,6-dichloroquinone-4-chloroimide, 2,6-dibromoquinone-4-chloroimide and 7,7',8,8'-tetracyanoquinodimethane. The charge-transfer complexes are isolated and characterized by elemental analysis, conductivity, IR, Raman, H-1 NMR spectra, X-ray powder diffraction, scanning electron microscopy and thermogravimetric analysis. The formation constants (K (CT)), molar extinction coefficients (E >(CT)), standard free energies (Delta G (0)), oscillator strengths (f), dipole moments (mu), resonance energies (R (N)) and ionization potentials (I (D)) are estimated. Thermodynamic parameters were computed from the thermal decomposition data.