Abstract
Considerable attention has recently been devoted to the formation of stable charge-transfer (CT) complexes that result from the reaction of drugs with acceptors. Intermolecular CT interactions of two drugs, barbituratic acid (Bar) and ephedrine hydrochloride (Eph), with different sigma- and pi-acceptors have been studied stoichiometrically, structurally (IR, Raman, H-1 NMR, and UV-Vis spectroscopy), thermally, and morphologically (SEM).