Abstract
Domperidone (Dom) possesses a potent antiemetic property, it increases the movements or contractions of the stomach and bowel. The current research aimed to synthesize and study the charge transfer (CT) complexes that originated from the interaction between Dom and different types of organic π-acceptors (PA, DNP, TCNQ, DDQ, DBQ, and DCQ). The targeted CT products were synthesized in methanol media, isolated, and thoroughly characterized by elemental analyses and spectroscopies (UV–Visible, IR, Raman, and 1H NMR). The thermal decomposition data of these products (from simultaneous TG analysis) were presented and discussed as well. Furthermore, the products' structural morphology was visualized by XRD and SEM-EDX. The results showed that the products have organized and homogeneously dispersed, uniform microstructures in the nanometer range.
Drug domperidone which is a typical antiemetic agent was complexed with six π-acceptors. The products were synthesized, isolated and fully characterized spectroscopically, thermally and morphologically. SEM and XRD analyses suggest that the products possess uniform microstructures with well-organized nano-sized particles having a main diameter in the range of 20–50 nm. The β values are correlated strongly with the particle size which indicate that the broadening in the highest line of the products decreased as particle size increased. [Display omitted]
•Drug domperidone was complexed with several acceptors via CT interaction.•Products were spectroscopically, thermally and morphologically characterized.•Several spectroscopic and thermodynamic parameters were evaluated.•Complexation occurs through hydrogen bonding and π → π* interactions.•The products have organized morphologies in the nanometer range.