Abstract
The aim of current study was to identify fatty acid composition of oil extracted from Euphorbia Pulcherrima. The oil sample was analysis using Gas chromatography coupled to mass spectrometer. The results obtained showed the presence of saturated and unsaturated fatty acid in Euphorbia Pulcherrima. The major constituents identified for the first time were palmitic acid, methyl ester, (66.52%), stearic acid, methyl ester (20.62%), heptadecenoic acid, methyl ester (7.16%), docosanoic acid, methyl ester (4.44%), tetracosanoic acid methyl ester (3.98%), C18:2c; linolenic acid, methyl ester (3.40 %). The fixed oil was also assessed for antileishmanial and antifungal activity which exhibited good activity. In the antileishmanial activity the metacyclic and procyclic mastigotes were exposed to concentrations loo pg/mL, 5o pg/mL, and 25 mu g/mL of oil for 24 hours, 48 hours and 72 hours at 26 degrees C incubation period and after 72 hours. These oils eliminated comparatively greater number of L. tropica parasites at 100 mu g/mL concentrations with mean percent inhibition values of 60%. In the antifungal activity Aspergillus flavus among the tested pathogen was active showing 60 % growth inhibition similarly 25% growth inhibition was shown by oil against, Penicillium notatum.