Abstract
Twenty-two alkaloids, were isolated from Fumaria densiflora. Two of these alkaloids, N-methyl-5-hydroxystylopine chloride and fumaricine N-oxide, were isolated for the first time from natural sources. Parfumine and fumaritine, in concentrations ranging from 3 x 10(-7) to 9 x 10(-4) M, caused concentration-dependent relaxation of ileum longitudinal segment. Also, parfumine and fumaritine in concentrations ranging from 3 x 10(-4) to 9 x 10(-2) M, caused concentration - dependent decrease in heart rate of the isolated perfused heart. A concentration of parfumine of 3 x 10(-2) M increased but a higher concentration (9 x 10(-2) M) decreased the amplitude of contraction of the isolated perfused heart. On the other hand, fumaritine, in concentrations ranging from 3 x 10(-4) to 3 x 10(-2) M, caused concentration - dependent increase, but a higher concentration (9 x 10(-2) M) caused a decrease in the amplitude of contraction of the isolated perfused heart.
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