Abstract
Investigation of the chemical constituents ofSalvia judaicagrowing wild in Jordan led to the isolation and identification of 15 known compounds. These included: luteolin-3 '-methyl ether (1), indole-3-carboxyaldehyde (2),p-hydroxybenzaldehyde (3), tricin (4), apigenin (5), methyl isoferuloyl-7-(3,4-dihydroxyphenyl) lactate (6), methyl rosmarinate (7), rosmarinic acid (8), salvigenin (9),beta-sitosterol (10), 3 beta, 28-dihydroxyurs-12-ene (11), cirsilineol (12), 2,3-dihydroxyurs-12-en-28-oic acid (13),beta-sitosteryl glucoside (14), and tormentic acid (15). Compounds6and7exhibited strong radical scavenging and chelating activities as compared to alpha-tocopherol and ascorbic acid, compound7showed a 2-fold greater antioxidant activity as compared to compound6. Furthermore, low doses of compounds6and7were able to inhibit the growth of leukemic (HL-60, Jurkat, K562 and CCRF-SB) and solid tumor cells (MCF-7, MDA-MB-231 and Caco-2). Compound7showed a ca. 3-4-fold stronger cytotoxicity against the tested cells as compared to compound6.