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Chemical ligation from O-acyl isopeptides via 8-and 11-membered cyclic transition states
Journal article   Open access  Peer reviewed

Chemical ligation from O-acyl isopeptides via 8-and 11-membered cyclic transition states

Siva S. Panda, Mohamed Elagawany, Hadi M. Marwani, Eray Caliskan, Mirna El Khatib, Alexander Oliferenko, Khalid A. Alamry and Alan R. Katritzky
ARKIVOC free online journal of organic chemistry, Vol.2014(4), pp.91-106
10/02/2014
DOI: https://doi.org/10.3998/ark.5550190.p008.632

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Unprotected O-acylated serine and O-acylated threonine isopeptides have been synthesized, and their conversion to native tripeptides and tetrapeptides by O- to N-terminus transfer investigated. Ligations involving 8- and 11-membered cyclic transition states are shown experimentally and computationally to be more favorable than intermolecular cross-ligations.
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https://doi.org/10.3998/ark.5550190.p008.632View
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