Chemoenzymatic preparation of intermediates for the taxol side chain and analogs

Bimal K. Banik; Mahima Negi; Maghar S. Manhas; Ajay K. Bose

doi:10.3892/mmr_00000258

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Journal article

Chemoenzymatic preparation of intermediates for the taxol side chain and analogs

Bimal K. Banik, Mahima Negi, Maghar S. Manhas and Ajay K. Bose

Molecular medicine reports, Vol.3(2), pp.317-318

01/03/2010

DOI: https://doi.org/10.3892/mmr_00000258

PMID: 21472240

Abstract

Life Sciences & Biomedicine

Medicine, Research & Experimental

Oncology

Research & Experimental Medicine

Science & Technology

In the present study, optically active cis and trans alpha-hydroxy-beta-lactams were prepared by Baker's yeast reduction of a racemic alpha-keto-beta-lactam and by the hydrolysis of a racemic alpha-acetoxy beta-lactam with the resting cells of Bacillus Subtilis.

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Title: Chemoenzymatic preparation of intermediates for the taxol side chain and analogs
Creators - without role: Bimal K. Banik - Department of Chemistry, The University of Texas Pan American, Edinburg, TX 78539, USA. banik@panam.edu
Mahima Negi - Stevens Institute of Technology
Maghar S. Manhas - Stevens Institute of Technology
Ajay K. Bose - Stevens Institute of Technology
Publication Details: Molecular medicine reports, Vol.3(2), pp.317-318
Publisher: Spandidos Publ Ltd
Number of pages: 2
Grant note: Howard Hughes Medical Institute 2S06M008038-38 / NIH-SCORE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Identifiers: 9925011008331
Academic Unit: Prince Mohammad Bin Fahd University
Language: English
Resource Type: Journal article