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Chemoenzymatic synthesis of ( R)- and ( S)-tembamide, aegeline and denopamine by a one-pot lipase resolution protocol
Journal article   Peer reviewed

Chemoenzymatic synthesis of ( R)- and ( S)-tembamide, aegeline and denopamine by a one-pot lipase resolution protocol

Ahmed Kamal, Ahmad Ali Shaik, Mahendra Sandbhor and M. Shaheer Malik
Tetrahedron: asymmetry, Vol.15(24), pp.3939-3944
13/12/2004
DOI: https://doi.org/10.1016/j.tetasy.2004.11.013

Abstract

[Display omitted] An efficient synthesis of optically active β-azido alcohols from their ketoazides by a one-pot reduction and an in situ lipase resolution protocol is described. The synthetic utility of this procedure has been illustrated by its application in the practical synthesis of both enantiomers of the natural hydroxyamides, tembamide, aegeline and the cardiac drug denopamine, with high enantioselectivities.

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