Abstract
Drug delivery systems with controlled release have been considered important tools for the treatment of various diseases. The efficacy of the drug can be enhanced by increasing its solubility, stability, bioavailability, and specific site delivery. Herein, we investigated cisplatin (cisP) loading efficacy and release potentiality on chitosan (CS) functionalized with magnetite (M), silicon dioxide (S), and graphene oxide (GO) nanoparticles. Different nanocomposites [chitosan-coated magnetite, silicon dioxide, and graphene oxide (CS/M/S/GO); chitosan-coated magnetite and silicon dioxide (CS/M/S); chitosan-coated silicon dioxide (CS/S); and chitosan-coated magnetite (CS/M)] were prepared. The prepared nanocomposites were characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR), scanning electron microscopy, transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDS). DFT calculations were employed to explore the interaction mechanism of cisP with a selected chitosan-functionalized nanocomposite in the gas phase and water media. The UV–Vis spectroscopy was used to study cisP loading and release from the prepared nanocomposites. The results showed that the highest loading efficacy was achieved by CS/M and CS/M/S/GO nanocomposites (87% and 84% respectively). While the releasing potentiality for CS/M composite was the highest compared with the other ones (91%).
Synthesis, characterization and DFT studies of four different nanocomposites of chitosan, magnetite, silicon dioxide, and graphene oxide as efficient cisplatin drug delivery systems. [Display omitted]
•Fabrication of chitosan, magnetite, silicon dioxide, and graphene oxide nanocomposites•Investigation of cisplatin drug loading efficacy on the as-fabricated nanocomposites•Investigation of release potentiality of the loaded cisplatin drug•The DFT calculations of the interaction mechanism of cisplatin drug with the nanocomposites•The magnetite chitosan nanocomposite has better loading and releasing drug efficiency.