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Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes
Journal article   Peer reviewed

Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes

Fei Wang, Wei Zhang, Jieming Zhu, Huaifeng Li, Kuo-Wei Huang and Jinbo Hu
Chemical communications (Cambridge, England), Vol.47(8), pp.2411-2413
01/01/2011
DOI: https://doi.org/10.1039/c0cc04548a
PMID: 21170456

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
A chloride ion-catalyzed generation of difluorocarbene from a relatively non-toxic and inexpensive precursor, Me3SiCF2Cl (1), under mild and neutral conditions leads to an efficient preparation of gem-difluorocyclopropenes and difluorocyclopropanes through [2 + 1] cycloaddition reactions with alkynes and alkenes, respectively.

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