Abstract
Nine compounds including beta-amyrin (1), erythrodiol (2), oleanolic acid (3), 3 beta-hydroxy 11,13(18)-oleanadien-28-oic-acid (4), glycyrrnetinic acid (5) 2 alpha,3 beta-dihydroxyolean-12-en-28-methyl ester (6), 2 alpha,3 beta-dihydroxyolean-12-en-28-oic acid (7), 2 alpha,3 beta,24-trihydroxyolean-12-28-oic acid (8) and 2 alpha,3 beta,19 beta-trihydroxyurs-12-en-28-oic acid (9), have been isolated from Perovskia atriplicifolia. Their structures have been established With the help Of different spectral data. All of these compounds were tested for cholinesterase inhibitory activity. Among the tested compounds, 8 and 9 were found to be the most active against both enzymes, with a significant butyrylcbolinesterase (BChB) inhibitory activity demonstrating IC50 values 9.50 and 13.52 mM, respectively, compared to galanthamine standard (IC50: 8,51 InM).