Abstract
Brachyuran aquaculture is gaining attention due to its high market value across the globe. In efforts to maximize the benefits of monosex culture in brachyurans, sex manipulation techniques benefit from the knowledge of sex determination system. However, unlike fish, information on the sex determination of decapod crustaceans including brachyurans remains disorganized. The compilation of literature shows most studies focused primarily on economically important brachyuran species and that the male heterogamety (XX/XY) or female heterogamety (ZW/ZZ) genetic sex determination system dominates among brachyuran species. Although the master regulatory gene in brachyuran species remains unknown, an increasing number of sex determination-related candidate genes are emerging. The current knowledge on the sex determination system of brachyurans could pave the way for the future establishment of breeding programs and the development of monosex culture systems in high-value brachyuran species.