Abstract
Objective: To present trends of resistance to ciprofloxacin among common organisms isolated at King Khalid University Hospital (KKUH) between 2001-2005.
Methods: Ciprofloxacin susceptibility of all isolates of Gram negative and Gram positive organisms were retrospectively obtained during the period from 2001-2005 in KKUH. Data from intensive care unit (ICU) and non-ICU patients were separately analyzed.
Results: Escherichia coli (E.coli) resistance increased from 10% in 2001 to 22% in 2005. Enterobacter cloacae (Ent.cloacae) resistance decreased from 11-14% in 2003 -2004 to 7% as in 2001 and 2005. Klebsiella pneumoniae (K.pneumoniae) resistance fluctuated from 6% in 2002 and 2003, 13% in 2004 to 6% in 2005. Pseudomonas aeruginosa (P.aeruginosa) resistance ranged from 7% - 8% during this study period white that of Acinetobacter spp. ranged between 45% to 62% and Staphylococcus aureus (S.aureus) resistance doubled from 18% in 2001 to 39% in 2005. None of Streptococcus pneumoniae (S.pneumoniae) isolates showed resistance to ciprofloxacin. Isolates of E.coli, Acinetobacter spp. and S.aureus from non-ICU patients showed higher resistance to ciprofloxacin than isolates from ICU patients while K.pneumoniae and P.aerusinosa showed higher resistance from ICU patients than isolates from non-ICU patients.
Conclusion: Ciprofloxacin resistance among many Gram negative species and S.aureus is an increasing threat among many Gram negative species and S.aureus in our hospital in both ICU and non-ICU patients.