Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study

Hakan Erdem; Magdalena Baymakova; Sevil Alkan; Amel Letaief; Wissal Ben Yahia; Farouq Dayyab; Entela Kolovani; Svjetlana Grgic; Federica Cosentino; Imran Hasanoglu; Reham Khedr; Andrea Marino; Abdullah Umut Pekok; Fatma Eser; Jurica Arapovic; Hatice Rahmet Guner; Ionela-Larisa Miftode; Kostadin Poposki; Gamze Sanlidag; Alper Tahmaz; Oguz Resat Sipahi; Egidia Gabriela Miftode; Serkan Oncu; Meliha Cagla-Sonmezer; Syam Kumar Addepalli; Ilad Alavi Darazam; Hema Prakash Kumari; Meliha Meriç Koc; Meela Ranjith Kumar; Suresh Babu Sayana; Ahmed Ashraf Wegdan; Fatma Amer; Mehmet Resat Ceylan; Amani El-Kholy; Taylan Onder; Hamed Azhdari Tehrani; Atousa Hakamifard; Bircan Kayaaslan; Ghaydaa Shehata; Hulya Caskurlu; Nagwa Mostafa El-Sayed; Seyed Erfan Mortazavi; Mohammad Pourali; Umran Elbahr; Sholpan Kulzhanova; Tarkan Yetisyigit; Sahar Ahmed Saad; Yasemin Cag; Gulden Eser-Karlidag; Natalia Pshenichnaya; Maya Belitova; Nasim Akhtar; Fahad Al-Majid; Muge Ayhan; Mumtaz Ali Khan; Massimiliano Lanzafame; Mateja Jankovic Makek; Emmanuel Nsutebu; Antonio Cascio; Emine Kubra Dindar-Demiray; Emine Unal Evren; Rama Kalas; Ayşe Kaya Kalem; Rusmir Baljić; Aamer Ikram; Selcuk Kaya; Anna Liskova; Balint Gergely Szabo; Bilal Ahmad Rahimi; Esmeray Mutlu-Yilmaz; Alper Sener; Jordi Rello

doi:10.1007/s10096-023-04561-5

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Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study

Journal article

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Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study

Hakan Erdem, Magdalena Baymakova, Sevil Alkan, Amel Letaief, Wissal Ben Yahia, Farouq Dayyab, Entela Kolovani, Svjetlana Grgic, Federica Cosentino, Imran Hasanoglu, …

European journal of clinical microbiology & infectious diseases, Vol.42(4), pp.387-398

01/04/2023

DOI: https://doi.org/10.1007/s10096-023-04561-5

PMID: 36790531

Abstract

Collagen

Communicable Diseases - diagnosis

Communicable Diseases - epidemiology

Fever of Unknown Origin - diagnosis

Fever of Unknown Origin - epidemiology

Fever of Unknown Origin - etiology

HIV Infections

Humans

Retrospective Studies

Fever of unknown origin (FUO) is a serious challenge for physicians. The aim of the present study was to consider epidemiology and dynamics of FUO in countries with different economic development. The data of FUO patients hospitalized/followed between 1st July 2016 and 1st July 2021 were collected retrospectively and submitted from referral centers in 21 countries through ID-IRI clinical research platform. The countries were categorized into developing (low-income (LI) and lower middle-income (LMI) economies) and developed countries (upper middle-income (UMI) and high-income (HI) economies). This research included 788 patients. FUO diagnoses were as follows: infections (51.6%; n = 407), neoplasms (11.4%, n = 90), collagen vascular disorders (9.3%, n = 73), undiagnosed (20.1%, n = 158), miscellaneous diseases (7.7%, n = 60). The most common infections were tuberculosis (n = 45, 5.7%), brucellosis (n = 39, 4.9%), rickettsiosis (n = 23, 2.9%), HIV infection (n = 20, 2.5%), and typhoid fever (n = 13, 1.6%). Cardiovascular infections (n = 56, 7.1%) were the most common infectious syndromes. Only collagen vascular disorders were reported significantly more from developed countries (RR = 2.00, 95% CI: 1.19-3.38). FUO had similar characteristics in LI/LMI and UMI/HI countries including the portion of undiagnosed cases (OR, 95% CI; 0.87 (0.65-1.15)), death attributed to FUO (RR = 0.87, 95% CI: 0.65-1.15, p-value = 0.3355), and the mean duration until diagnosis (p = 0.9663). Various aspects of FUO cannot be determined by the economic development solely. Other development indices can be considered in future analyses. Physicians in different countries should be equally prepared for FUO patients.

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Title: Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study
Creators - without role: Hakan Erdem - Ankara
Magdalena Baymakova - Military Medical Academy
Sevil Alkan - Çanakkale Onsekiz Mart Üniversitesi
Amel Letaief - University of Sousse
Wissal Ben Yahia - University of Sousse
Farouq Dayyab - King Hamad University Hospital
Entela Kolovani - Mother Teresa Hospital
Svjetlana Grgic - University Clinical Hospital Mostar
Federica Cosentino - Ospedale Garibaldi
Imran Hasanoglu - Memorial Ankara Hospital
Reham Khedr - Children Cancer Hospital
Andrea Marino - Ospedale Garibaldi
Abdullah Umut Pekok - Gedik University
Fatma Eser - Memorial Ankara Hospital
Jurica Arapovic - University Clinical Hospital Mostar
Hatice Rahmet Guner - Ankara
Ionela-Larisa Miftode - Clinical Emergency Hospital Bucharest
Kostadin Poposki - Faculty
Gamze Sanlidag - Department of Infectious Diseases & Clinical Microbiology, Ege School of Medicine, Izmir, Turkey
Alper Tahmaz - Antalya Eğitim ve Araştırma Hastanesi
Oguz Resat Sipahi - Ege University
Egidia Gabriela Miftode - Clinical Emergency Hospital Bucharest
Serkan Oncu - Adnan Menderes University
Meliha Cagla-Sonmezer - Hacettepe University
Syam Kumar Addepalli - GITAM University
Ilad Alavi Darazam - Shahid Beheshti University of Medical Sciences
Hema Prakash Kumari - GITAM University
Meliha Meriç Koc - Bezmiâlem Vakıf Üniversitesi
Meela Ranjith Kumar - Government General Hospital
Suresh Babu Sayana - Government Medical College
Ahmed Ashraf Wegdan - Fayoum University
Fatma Amer - Zagazig University
Mehmet Resat Ceylan - Harran University
Amani El-Kholy - Cairo University
Taylan Onder - Çanakkale Onsekiz Mart Üniversitesi
Hamed Azhdari Tehrani - Shahid Beheshti University of Medical Sciences
Atousa Hakamifard - Shahid Beheshti University of Medical Sciences
Bircan Kayaaslan - Memorial Ankara Hospital
Ghaydaa Shehata - Assiut University
Hulya Caskurlu - Istanbul Medeniyet University
Nagwa Mostafa El-Sayed - Research Institute of Ophthalmology
Seyed Erfan Mortazavi - Shahid Beheshti University of Medical Sciences
Mohammad Pourali - Shahid Beheshti University of Medical Sciences
Umran Elbahr - King Hamad University Hospital
Sholpan Kulzhanova - Astana Medical University
Tarkan Yetisyigit - King Hamad University Hospital
Sahar Ahmed Saad - King Hamad University Hospital
Yasemin Cag - Istanbul Medeniyet University
Gulden Eser-Karlidag - Elazığ Eğitim ve Araştırma Hastanesi
Natalia Pshenichnaya - Central Research Institute of Epidemiology
Maya Belitova - Medical University of Sofia
Nasim Akhtar - Pakistan Institute of Medical Sciences
Fahad Al-Majid - King Saud University
Muge Ayhan - Memorial Ankara Hospital
Mumtaz Ali Khan - National Institute of Health
Massimiliano Lanzafame - Ospedale Santa Chiara
Mateja Jankovic Makek - University Hospital Centre Zagreb
Emmanuel Nsutebu - Sheikh Shakhbout Medical City
Antonio Cascio - University of Palermo
Emine Kubra Dindar-Demiray - Bitlis Eren University
Emine Unal Evren - University of Kyrenia
Rama Kalas - Sheikh Shakhbout Medical City
Ayşe Kaya Kalem - Memorial Ankara Hospital
Rusmir Baljić - KCU Sarajevo, Sarajevo, Bosnia and Herzegovina
Aamer Ikram - National Institute of Health
Selcuk Kaya - Karadeniz Technical University
Anna Liskova - Vysoká Škola Zdravotníctva a Sociálnej Práce sv. Alžbety
Balint Gergely Szabo - South Pest Central Hospital, National Institute of Hematology and Infectious Diseases, Budapest, Hungary
Bilal Ahmad Rahimi - Kandahar University
Esmeray Mutlu-Yilmaz - Samsun University
Alper Sener - Çanakkale Onsekiz Mart Üniversitesi
Jordi Rello - Vall d'Hebron Institut de Recerca
Publication Details: European journal of clinical microbiology & infectious diseases, Vol.42(4), pp.387-398
Identifiers: 9946812408331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article