Abstract
Objective
To evaluate the efficacy of trimethoprim-sulfamethoxazole and oral prednisolone in the treatment of ocular toxoplasmosis with zone-1 posterior pole and peri-papillary lesions.
Methods
Retrospective evaluation of records of patients in our tertiary care referral hospitals.
Results
22 eyes of 21 patients with active toxoplasma retino-choroiditis in zone -1 posterior pole and peri-papillary areas were included in the study. One patient developed active lesion in the fellow eye after 6 months which regressed after re-institution of the treatment.
There were 11 females and 10 males. Age varied between 18-52 (mean age 29 +/- 8.8) years. The follow-up period varied between 4- 46 (mean 15 +/- 11) months. All patients showed resolution of retino-choroiditis and improvement of visual acuity between 1-9 lines (mean 4.18 lines +/- 2.3). The mean lesion size pre-treatment was 0.89 disc diameters +/- 0.3 and post-treatment was 0.70 disc diameters +/- 0.28. The mean time taken for the sharpening of lesion borders was 2.3 +/- 0.4 (range 2-3) weeks. No complications reported with the medication.
Conclusion
The combination of trimethoprim-sulfamethoxazole and prednisolone is quite effective in treating the patients with active vision threatening posterior pole and peri-papillary toxoplasmosis lesions.