Abstract
Earlier studies reported DNA fragmentation index (DFI) threshold value by sperm chromatin structure assay (SCSA) with respect to ART outcome in the range of 27-30 per cent [4],[5] . [...]date, diagnostic work up of men with idiopathic infertility involves mainly semen analysis, but standard semen parameters are modest predictors of fertility potential. Studies have shown that reactive oxygen species (ROS) levels are elevated in about 68 per cent of infertile men [6],[8] and this is one of the most important factors in the aetiology of DNA damage, thus tests for sperm DNA quality are more informative and have diagnostic and prognostic implications [9],[10] . [...]this pilot study was planned with aim to assess ROS levels and DFI in cases with normal sperm parameters and highlight the need to assess ROS levels and DFI in infertile couples opting for ART or experiencing recurrent miscarriages. [...]all couples experiencing recurrent ART failure or RSA must be evaluated for sperm DNA integrity and ROS levels.