Abstract
Objectives: To study the role of inflammatory chemokine: monocyte chemoattractant protein-1 (MCP-1), and fibrogenic markers [transforming growth factor beta-1 (TGF-beta(1)), connective tissue growth factor (CTGF) and fibronectin (FN)] in diabetic nephropathy (DN).
Design and methods: This study included 17 control and 65 type 2 diabetic subjects (18 normoalbuminuric, 22 microalbuminuric and 25 macroalbuminuric). Demographic characteristics, diabetic index and kidney function tests were monitored. Serum TGF-beta(1), plasma CTGF, MCP-1 and FN levels were assayed.
Results: Microalbuminuric and macroalbuminuric subjects showed a significant elevation in TGF-beta(1), CTGF, MCP-1 and FN levels as compared with control and normoalbuminuric subjects. There was positive correlation between these markers and fasting plasma glucose, albumin excretion rate and with each other.
Conclusion: This study revealed the importance of these markers in DN pathogenesis which is powered by their association and thus the possibility of their use as biochemical markers in DN was suggested. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.