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Clonazepam in juvenile myoclonic epilepsy
Journal article   Peer reviewed

Clonazepam in juvenile myoclonic epilepsy

T Obeid and C P Panayiotopoulos
Epilepsia (Copenhagen), Vol.30(5), pp.603-606
01/09/1989
DOI: https://doi.org/10.1111/j.1528-1157.1989.tb05479.x
PMID: 2507306

Abstract

Adolescent Adult Carbamazepine - therapeutic use Circadian Rhythm - drug effects Clonazepam - therapeutic use Drug Combinations Epilepsies, Myoclonic - drug therapy Female Follow-Up Studies Humans Male Myoclonus - drug therapy Phenytoin - therapeutic use Prospective Studies Valproic Acid - therapeutic use
We studied the efficacy of clonazepam (CZP) in control of juvenile myoclonic epilepsy (JME) in 17 patients. CZP was very effective in controlling myoclonic jerks in all patients but did not suppress generalized tonic-clonic seizures (GTCS). A disadvantage occurs because the patient is deprived of the warning jerks which presage the onset of GTCS. The circadian rhythm of the GTCS was also changed in two patients.

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