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Cobalt-Catalyzed Oxidative Annulation of Nitrogen-Containing Arenes with Alkynes: An Atom-Economical Route to Heterocyclic Quaternary Ammonium Salts
Journal article   Peer reviewed

Cobalt-Catalyzed Oxidative Annulation of Nitrogen-Containing Arenes with Alkynes: An Atom-Economical Route to Heterocyclic Quaternary Ammonium Salts

Sekar Prakash, Krishnamoorthy Muralirajan and Chien-Hong Cheng
Angewandte Chemie (International ed.), Vol.55(5), pp.1844-1848
26/01/2016
PMID: 26791886

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
Four cobalt-catalyzed oxidative annulation reactions of nitrogen-containing arenes with alkynes proceeds by C-H activation, thus leading to biologically useful quaternary ammonium salts, including pyridoisoquinolinium, cinnolinium, isoquinolinium, and quinolizinium salts, in high yields. The results are comparable to those reactions catalyzed by rhodium and ruthenium complexes. The transformation of the salts into various N-heterocycles has also been demonstrated.

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