Abstract
Body weight loss, inefficiency of feed utilization, diarrhea, ruffled hair and enterohepatonephrotoxicity were effects on male Wistar rats fed diet containing 10 % Cassia senna or 10 % Citrullus colocynthis ripe fruits for 6 w. Rats fed a 1:1 mixture (5% + 5%) of fruits from these plants were more adversery affected and had deaths than rats fed the individual plants. The changes associated with the macrocytic hypochromic anemia and leukopenia were increased serum AST, ALT and ALP activities, increased urea, and decreased total protein, albumin and calcium. Serum bilirubin concentration did not change.