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Combined drug design of potential Mycobacterium tuberculosis and HIV-1 inhibitors: 3 ',4 '-di-substituted-4 ' H-spiro [isothiochromene-3,5 '-isoxazol]-4(1H)-one
Journal article   Open access  Peer reviewed

Combined drug design of potential Mycobacterium tuberculosis and HIV-1 inhibitors: 3 ',4 '-di-substituted-4 ' H-spiro [isothiochromene-3,5 '-isoxazol]-4(1H)-one

B. Bennani, A. Kerbal, M. Daoudi, B. Filali Baba, G. Al Houari, A. F. Jalbout, M. Mimouni, M. Benazza, G. Demailly, M. Akkurt, …
ARKIVOC free online journal of organic chemistry, Vol.2007(16), pp.19-40
05/11/2007
DOI: https://doi.org/10.3998/ark.5550190.0008.g03

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
We report herein the design and synthesis of 17 new spiroheterocycles 10-26, on the basis of two hypothetical pharmacophore structures designed to interact with both of Mycobacterium tuberculosis bacteria and HIV-1 virus. The in vitro biological evaluation of these compounds allowed us to point out seven new potential non-nucleoside hits, with MIC values in the range of 6.25 mu g/mL and two new potential anti-HIV-1 inhibitors.
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https://doi.org/10.3998/ark.5550190.0008.g03View
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