Common variants associated with plasma triglycerides and risk for coronary artery disease

Ron Do; Cristen J. Willer; Ellen M. Schmidt; Sebanti Sengupta; Chi Gao; Gina M. Peloso; Stefan Gustafsson; Stavroula Kanoni; Andrea Ganna; Jin Chen; Martin L. Buchkovich; Samia Mora; Jacques S. Beckmann; Jennifer L. Bragg-Gresham; Hsing-Yi Chang; Ayse Demirkan; Heleen M. Den Hertog; Louise A. Donnelly; Georg B. Ehret; Tonu Esko; Mary F. Feitosa; Teresa Ferreira; Krista Fischer; Pierre Fontanillas; Ross M. Fraser; Daniel F. Freitag; Deepti Gurdasani; Kauko Heikkila; Elina Hyppoenen; Aaron Isaacs; Anne U. Jackson; Asa Johansson; Toby Johnson; Marika Kaakinen; Johannes Kettunen; Marcus E. Kleber; Xiaohui Li; Jian'an Luan; Leo-Pekka Lyytikainen; Patrik K. E. Magnusson; Massimo Mangino; Evelin Mihailov; May E. Montasser; Martina Mueller-Nurasyid; Ilja M. Nolte; Jeffrey R. O'Connell; Cameron D. Palmer; Markus Perola; Ann-Kristin Petersen; Serena Sanna; Richa Saxena; Susan K. Service; Sonia Shah; Dmitry Shungin; Carlo Sidore; Ci Song; Rona J. Strawbridge; Ida Surakka; Toshiko Tanaka; Tanya M. Teslovich; Gudmar Thorleifsson; Evita G. Van den Herik; Benjamin F. Voight; Kelly A. Volcik; Lindsay L. Waite; Andrew Wong; Ying Wu; Weihua Zhang; Devin Absher; Gershim Asiki; Ines Barroso; Latonya F. Been; Jennifer L. Bolton; Lori L. Bonnycastle; Paolo Brambilla; Mary S. Burnett; Giancarlo Cesana; Maria Dimitriou; Alex S. F. Doney; Angela Doering; Paul Elliott; Stephen E. Epstein; Gudmundur Ingi Eyjolfsson; Bruna Gigante; Mark O. Goodarzi; Harald Grallert; Martha L. Gravito; Christopher J. Groves; Goran Hallmans; Anna-Liisa Hartikainen; Caroline Hayward; Dena Hernandez; Andrew A. Hicks; Hilma Holm; Yi-Jen Hung; Thomas Illig; Michelle R. Jones; Pontiano Kaleebu; John J. P. Kastelein; Kay-Tee Khaw; Eric Kim; Norman Klopp; Pirjo Komulainen; Meena Kumari; Claudia Langenberg; Terho Lehtimaki; Shih-Yi Lin; Jaana Lindstrom; Ruth J. F. Loos; Francois Mach; Wendy L. McArdle; Christa Meisinger; Braxton D. Mitchell; Gabrielle Mueller; Ramaiah Nagaraja; Narisu Narisu; Tuomo V. M. Nieminen; Rebecca N. Nsubuga; Isleifur Olafsson; Ken K. Ong; Aarno Palotie; Theodore Papamarkou; Cristina Pomilla; Anneli Pouta; Daniel J. Rader; Muredach P. Reilly; Paul M. Ridker; Fernando Rivadeneira; Igor Rudan; Aimo Ruokonen; Nilesh Samani; Hubert Scharnagl; Janet Seeley; Kaisa Silander; Alena Stancakova; Kathleen Stirrups; Amy J. Swift; Laurence Tiret; Andre G. Uitterlinden; L. Joost van Pelt; Sailaja Vedantam; Nicholas Wainwright; Cisca Wijmenga; Sarah H. Wild; Gonneke Willemsen; Tom Wilsgaard; James F. Wilson; Elizabeth H. Young; Jing Hua Zhao; Linda S. Adair; Dominique Arveiler; Themistocles L. Assimes; Stefania Bandinelli; Franklyn Bennett; Murielle Bochud; Bernhard O. Boehm; Dorret I. Boomsma; Ingrid B. Borecki; Stefan R. Bornstein; Pascal Bovet; Michel Burnier; Harry Campbell; Aravinda Chakravarti; John C. Chambers; Yii-Der Ida Chen; Francis S. Collins; Richard S. Cooper; John Danesh; George Dedoussis; Ulf de Faire; Alan B. Feranil; Jean Ferrieres; Luigi Ferrucci; Nelson B. Freimer; Christian Gieger; Leif C. Groop; Vilmundur Gudnason; Ulf Gyllensten; Anders Hamsten; Tamara B. Harris; Aroon Hingorani; Joel N. Hirschhorn; Albert Hofman; G. Kees Hovingh; Chao Agnes Hsiung; Steve E. Humphries; Steven C. Hunt; Kristian Hveem; Carlos Iribarren; Marjo-Riitta Jarvelin; Antti Jula; Mika Kahonen; Jaakko Kaprio; Antero Kesaniemi; Mika Kivimaki; Jaspal S. Kooner; Peter J. Koudstaal; Ronald M. Krauss; Diana Kuh; Johanna Kuusisto; Kirsten O. Kyvik; Markku Laakso; Timo A. Lakka; Lars Lind; Cecilia M. Lindgren; Nicholas G. Martin; Winfried Maerz; Mark I. McCarthy; Colin A. McKenzie; Pierre Meneton; Andres Metspalu; Leena Moilanen; Andrew D. Morris; Patricia B. Munroe; Inger Njolstad; Nancy L. Pedersen; Chris Power; Peter P. Pramstaller; Jackie F. Price; Bruce M. Psaty; Thomas Quertermous; Rainer Rauramaa; Danish Saleheen; Veikko Salomaa; Dharambir K. Sanghera; Jouko Saramies; Peter E. H. Schwarz; Wayne H-H Sheu; Alan R. Shuldiner; Agneta Siegbahn; Tim D. Spector; Kari Stefansson; David P. Strachan; Bamidele O. Tayo; Elena Tremoli; Jaakko Tuomilehto; Matti Uusitupa; Cornelia M. van Duijn; Peter Vollenweider; Lars Wallentin; Nicholas J. Wareham; John B. Whitfield; Bruce H. R. Wolffenbuttel; David Altshuler; Jose M. Ordovas; Eric Boerwinkle; Colin N. A. Palmer; Unnur Thorsteinsdottir; Daniel I. Chasman; Jerome I. Rotter; Paul W. Franks; Samuli Ripatti; L. Adrienne Cupples; Manjinder S. Sandhu; Stephen S. Rich; Michael Boehnke; Panos Deloukas; Karen L. Mohlke; Erik Ingelsson; Goncalo R. Abecasis; Mark J. Daly; Benjamin M. Neale; Sekar Kathiresan

doi:10.1038/ng.2795

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Common variants associated with plasma triglycerides and risk for coronary artery disease

Journal article

Peer reviewed

Common variants associated with plasma triglycerides and risk for coronary artery disease

Ron Do, Cristen J. Willer, Ellen M. Schmidt, Sebanti Sengupta, Chi Gao, Gina M. Peloso, Stefan Gustafsson, Stavroula Kanoni, Andrea Ganna, Jin Chen, …

Nature genetics, Vol.45(11), pp.1345-1352

01/11/2013

DOI: https://doi.org/10.1038/ng.2795

PMCID: PMC3904346

PMID: 24097064

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.

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Title: Common variants associated with plasma triglycerides and risk for coronary artery disease
Creators - without role: Ron Do
Cristen J. Willer
Ellen M. Schmidt
Sebanti Sengupta
Chi Gao
Gina M. Peloso
Stefan Gustafsson
Stavroula Kanoni
Andrea Ganna
Jin Chen
Martin L. Buchkovich
Samia Mora
Jacques S. Beckmann
Jennifer L. Bragg-Gresham
Hsing-Yi Chang
Ayse Demirkan
Heleen M. Den Hertog - Erasmus MC
Louise A. Donnelly - University of Dundee
Georg B. Ehret - College Station Medical Center
Tonu Esko - University of Tartu
Mary F. Feitosa - Supreme Council Of Health
Teresa Ferreira - University of Oxford
Krista Fischer - University of Tartu
Pierre Fontanillas
Ross M. Fraser - University of Edinburgh
Daniel F. Freitag - University of Cambridge
Deepti Gurdasani - University of Cambridge
Kauko Heikkila - University of Helsinki
Elina Hyppoenen - Biostat
Aaron Isaacs - College Station Medical Center
Anne U. Jackson
Asa Johansson - Uppsala University
Toby Johnson - Queen Mary University of London
Marika Kaakinen - University of Oulu
Johannes Kettunen - University of Helsinki
Marcus E. Kleber - University of Ulm
Xiaohui Li - College Station Medical Center
Jian'an Luan - Massachusetts Rehabilitation Commission
Leo-Pekka Lyytikainen - Tampere University
Patrik K. E. Magnusson
Massimo Mangino - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Evelin Mihailov - University of Tartu
May E. Montasser - Supreme Council Of Health
Martina Mueller-Nurasyid - Helmholtz Zentrum München
Ilja M. Nolte - University of Groningen
Jeffrey R. O'Connell - Supreme Council Of Health
Cameron D. Palmer - Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Markus Perola - University of Tartu
Ann-Kristin Petersen - Helmholtz Zentrum München
Serena Sanna - CNR, Ist Ric Genet & Biomed, Monserrato, Italy
Richa Saxena
Susan K. Service - Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA 90024 USA
Sonia Shah - UCL, Dept Epidemiol & Publ Hlth, Genet Epidemiol Grp, London, England
Dmitry Shungin - Lund University
Carlo Sidore - CNR, Ist Ric Genet & Biomed, Monserrato, Italy
Ci Song
Rona J. Strawbridge - Karolinska Institutet
Ida Surakka - University of Helsinki
Toshiko Tanaka - NIH, Clin Res Branch, Baltimore, MD USA
Tanya M. Teslovich
Gudmar Thorleifsson - Amgen
Evita G. Van den Herik - Erasmus MC
Benjamin F. Voight - Supreme Council Of Health
Kelly A. Volcik - Supreme Council Of Health
Lindsay L. Waite - HudsonAlpha Inst Biotechnol, Huntsville, TX USA
Andrew Wong - Massachusetts Rehabilitation Commission
Ying Wu
Weihua Zhang - University of London
Devin Absher - HudsonAlpha Inst Biotechnol, Huntsville, TX USA
Gershim Asiki - Uganda Virus Research Institute
Ines Barroso - University of Cambridge
Latonya F. Been - University of Oklahoma
Jennifer L. Bolton - University of Edinburgh
Lori L. Bonnycastle - NHGRI, NIH, Genome Technol Branch, Bethesda, MD 20892 USA
Paolo Brambilla - University of Milano-Bicocca
Mary S. Burnett - MedStar Hlth Res Inst, Hyattsville, MD USA
Giancarlo Cesana - University of Milano-Bicocca
Maria Dimitriou - Harokopio University of Athens
Alex S. F. Doney - University of Dundee
Angela Doering - Helmholtz Zentrum München
Paul Elliott - University of Oulu
Stephen E. Epstein - MedStar Hlth Res Inst, Hyattsville, MD USA
Gudmundur Ingi Eyjolfsson - Lab Mjodd, Reykjavik, Iceland
Bruna Gigante - Karolinska Institutet
Mark O. Goodarzi - College Station Medical Center
Harald Grallert - Helmholtz Zentrum München
Martha L. Gravito - University of Oklahoma
Christopher J. Groves - University of Oxford
Goran Hallmans - Umeå University
Anna-Liisa Hartikainen - Oulu Univ Hosp, Dept Clin Sci Obstet & Gynecol, Oulu, Finland
Caroline Hayward - College Station Medical Center
Dena Hernandez - NIA, Neurogenet Lab, Bethesda, MD 20892 USA
Andrew A. Hicks - European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy
Hilma Holm - deCODE Genet Amgen, Reykjavik, Iceland
Yi-Jen Hung - College Station Medical Center
Thomas Illig - Helmholtz Zentrum München
Michelle R. Jones - College Station Medical Center
Pontiano Kaleebu - Uganda Virus Research Institute
John J. P. Kastelein - University of Amsterdam
Kay-Tee Khaw - University of Cambridge
Eric Kim - College Station Medical Center
Norman Klopp - Helmholtz Zentrum München
Pirjo Komulainen - College Station Medical Center
Meena Kumari - UCL, Dept Epidemiol & Publ Hlth, Genet Epidemiol Grp, London, England
Claudia Langenberg - Massachusetts Rehabilitation Commission
Terho Lehtimaki - Tampere University
Shih-Yi Lin - Supreme Council Of Health
Jaana Lindstrom - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Ruth J. F. Loos - Massachusetts Rehabilitation Commission
Francois Mach - College Station Medical Center
Wendy L. McArdle - University of Bristol
Christa Meisinger - Helmholtz Zentrum München
Braxton D. Mitchell - Supreme Council Of Health
Gabrielle Mueller - College Station Medical Center
Ramaiah Nagaraja - NIA, Genet Lab, Baltimore, MD 21224 USA
Narisu Narisu - NHGRI, NIH, Genome Technol Branch, Bethesda, MD 20892 USA
Tuomo V. M. Nieminen - University of Tampere
Rebecca N. Nsubuga - Uganda Virus Research Institute
Isleifur Olafsson - Landspitali Univ Hosp, Dept Clin Biochem, Reykjavik, Iceland
Ken K. Ong - Massachusetts Rehabilitation Commission
Aarno Palotie - University of Helsinki
Theodore Papamarkou - University of Cambridge
Cristina Pomilla - University of Cambridge
Anneli Pouta - Oulu Univ Hosp, Dept Clin Sci Obstet & Gynecol, Oulu, Finland
Daniel J. Rader - Supreme Council Of Health
Muredach P. Reilly - Supreme Council Of Health
Paul M. Ridker
Fernando Rivadeneira - College Station Medical Center
Igor Rudan - University of Edinburgh
Aimo Ruokonen - University of Oulu
Nilesh Samani - Glenfield Gen Hosp, Natl Inst Hlth Res, Leicester Cardiovasc Biomed Res Unit, Leicester LE3 9QP, Leics, England
Hubert Scharnagl - University of Graz
Janet Seeley - Uganda Virus Research Institute
Kaisa Silander - University of Helsinki
Alena Stancakova - University of Eastern Finland
Kathleen Stirrups
Amy J. Swift - NHGRI, NIH, Genome Technol Branch, Bethesda, MD 20892 USA
Laurence Tiret - Université Paris Cité
Andre G. Uitterlinden - College Station Medical Center
L. Joost van Pelt - University of Groningen
Sailaja Vedantam - Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Nicholas Wainwright - University of Cambridge
Cisca Wijmenga - University of Groningen
Sarah H. Wild - University of Edinburgh
Gonneke Willemsen - University of Amsterdam
Tom Wilsgaard - College Station Medical Center
James F. Wilson - University of Edinburgh
Elizabeth H. Young - University of Cambridge
Jing Hua Zhao - Massachusetts Rehabilitation Commission
Linda S. Adair - Univ N Carolina, Dept Nutr, Chapel Hill, NC USA
Dominique Arveiler - University of Strasbourg
Themistocles L. Assimes - Stanford University
Stefania Bandinelli - Florence
Franklyn Bennett - Univ W Indies, Dept Pathol, Mona, Jamaica
Murielle Bochud - University of Lausanne
Bernhard O. Boehm - University of Ulm
Dorret I. Boomsma - University of Amsterdam
Ingrid B. Borecki - Supreme Council Of Health
Stefan R. Bornstein - College Station Medical Center
Pascal Bovet - University of Lausanne
Michel Burnier - University of Lausanne
Harry Campbell - University of Edinburgh
Aravinda Chakravarti - Johns Hopkins University
John C. Chambers - University of London
Yii-Der Ida Chen - College Station Medical Center
Francis S. Collins - NHGRI, NIH, Genome Technol Branch, Bethesda, MD 20892 USA
Richard S. Cooper - Supreme Council Of Health
John Danesh - University of Cambridge
George Dedoussis - Harokopio University of Athens
Ulf de Faire - Karolinska Institutet
Alan B. Feranil - University of San Carlos
Jean Ferrieres - Supreme Council Of Health
Luigi Ferrucci - NIH, Clin Res Branch, Baltimore, MD USA
Nelson B. Freimer - Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA 90024 USA
Christian Gieger - Helmholtz Zentrum München
Leif C. Groop - Lund University
Vilmundur Gudnason - Iceland Heart Assoc, Kopavogur, Iceland
Ulf Gyllensten - Uppsala University
Anders Hamsten - Karolinska Institutet
Tamara B. Harris - NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
Aroon Hingorani - UCL, Dept Epidemiol & Publ Hlth, Genet Epidemiol Grp, London, England
Joel N. Hirschhorn - Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Albert Hofman - College Station Medical Center
G. Kees Hovingh - University of Amsterdam
Chao Agnes Hsiung - Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Taiwan
Steve E. Humphries - UCL, Inst Cardiovasc Sci, British Heart Fdn Labs, London, England
Steven C. Hunt - University of Utah
Kristian Hveem - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Nord Trondelag Hlth Study HUNT Res Ctr, Levanger, Norway
Carlos Iribarren
Marjo-Riitta Jarvelin - University of Oulu
Antti Jula - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Turku, Finland
Mika Kahonen - University of Tampere
Jaakko Kaprio - University of Helsinki
Antero Kesaniemi - University of Oulu
Mika Kivimaki - UCL, Dept Epidemiol & Publ Hlth, Genet Epidemiol Grp, London, England
Jaspal S. Kooner - Imperial Coll Healthcare Natl Hlth Serv NHS Trust, London, England
Peter J. Koudstaal - Erasmus MC
Ronald M. Krauss - Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA
Diana Kuh - Massachusetts Rehabilitation Commission
Johanna Kuusisto - University of Eastern Finland
Kirsten O. Kyvik - Univ So Denmark, Inst Reg Hlth Serv Res, Odense, Denmark
Markku Laakso - University of Eastern Finland
Timo A. Lakka - College Station Medical Center
Lars Lind - Uppsala University
Cecilia M. Lindgren - University of Oxford
Nicholas G. Martin - College Station Medical Center
Winfried Maerz - Heidelberg University
Mark I. McCarthy - University of Oxford
Colin A. McKenzie - College Station Medical Center
Pierre Meneton - Inserm
Andres Metspalu - University of Tartu
Leena Moilanen - College Station Medical Center
Andrew D. Morris - University of Dundee
Patricia B. Munroe - Queen Mary University of London
Inger Njolstad - College Station Medical Center
Nancy L. Pedersen
Chris Power - Biostat
Peter P. Pramstaller - European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy
Jackie F. Price - University of Edinburgh
Bruce M. Psaty - University of Washington
Thomas Quertermous - Stanford University
Rainer Rauramaa - College Station Medical Center
Danish Saleheen - University of Cambridge
Veikko Salomaa - Natl Inst Hlth & Welf, Unit Chron Dis Epidemiol & Prevent, Helsinki, Finland
Dharambir K. Sanghera - University of Oklahoma
Jouko Saramies - South Karelia Cent Hosp, Lappeenranta, Finland
Peter E. H. Schwarz - College Station Medical Center
Wayne H-H Sheu - College Station Medical Center
Alan R. Shuldiner - Supreme Council Of Health
Agneta Siegbahn - Uppsala University
Tim D. Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Kari Stefansson - Amgen
David P. Strachan - University of London
Bamidele O. Tayo - Supreme Council Of Health
Elena Tremoli - University of Milan
Jaakko Tuomilehto - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Matti Uusitupa - University of Eastern Finland
Cornelia M. van Duijn - College Station Medical Center
Peter Vollenweider - University of Lausanne
Lars Wallentin - Uppsala University
Nicholas J. Wareham - Massachusetts Rehabilitation Commission
John B. Whitfield - College Station Medical Center
Bruce H. R. Wolffenbuttel - University of Groningen
David Altshuler
Jose M. Ordovas - Natl Ctr Cardiovasc Invest, Dept Cardiovasc Epidemiol & Populat Genet, Madrid, Spain
Eric Boerwinkle - Supreme Council Of Health
Colin N. A. Palmer - University of Dundee
Unnur Thorsteinsdottir - Amgen
Daniel I. Chasman
Jerome I. Rotter - College Station Medical Center
Paul W. Franks - Lund University
Samuli Ripatti - University of Helsinki
L. Adrienne Cupples - Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Manjinder S. Sandhu - University of Cambridge
Stephen S. Rich - University of Virginia
Michael Boehnke
Panos Deloukas
Karen L. Mohlke
Erik Ingelsson - University of Oxford
Goncalo R. Abecasis
Mark J. Daly - Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
Benjamin M. Neale - University of Virginia
Sekar Kathiresan
Publication Details: Nature genetics, Vol.45(11), pp.1345-1352
Publisher: Springer Nature
Number of pages: 9
Grant note: UL1TR000124 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) MC_U106188470 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Fondation Leducq; Leducq Foundation ES/J023299/1 / Economic and Social Research Council; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) P30DK063491 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) ES/J023299/1 / ESRC; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) R01HL107816 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA PG/08/094/26019 / British Heart Foundation NF-SI-0512-10165 / National Institute for Health Research; National Institute for Health Research (NIHR) Donovan Family Foundation CZB/4/710 / Chief Scientist Office Massachusetts General Hospital; General Electric G0701863 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission T32HL007208 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR)
Identifiers: 9934855708331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article