Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens

Ajmal Khan; Humera Jabeen; Touqeer Ahmad; Najeeb Ur Rehman; Saleha Suleman Khan; Huma Shareef; Rizwana Sarwar; Saira Yahya; Nusrat Hussain; Jalal Uddin; Javid Hussain; Ahmed Al-Harrasi

doi:10.1080/21691401.2022.2144340

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Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens

Journal article

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Peer reviewed

Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens

Ajmal Khan, Humera Jabeen, Touqeer Ahmad, Najeeb Ur Rehman, Saleha Suleman Khan, Huma Shareef, Rizwana Sarwar, Saira Yahya, Nusrat Hussain, Jalal Uddin, …

Artificial cells, nanomedicine, and biotechnology, Vol.50(1), pp.312-321

31/12/2022

DOI: https://doi.org/10.1080/21691401.2022.2144340

PMID: 36380462

Abstract

antibiofilm

Cephradine

FTIR

nanoparticles

TEM

Infections caused by drug-resistant bacteria are major health concerns worldwide. We successfully synthesized cephradine gold nanoparticles (Ceph-Au NPs) and cephradine silver nanoparticles (Ceph-Ag NPs) and compared their efficacy against resistant human pathogens. X-Ray diffraction (XRD), Atomic Force Microscopy (AFM) and Transmission Electron Microscopy (TEM) results showed that average particle size of Ceph-Au NPs and Ceph-Ag NPs were 7 and 12 nm, respectively. Fourier Transform Infra-red spectroscopy (FTIR) spectra revealed the conjugation of -NH 2 and -OH functional moieties with the nanoparticle (NP) surfaces. These NPs significantly inhibited the biofilm of Streptococcus mutans (S. mutans) and methicillin-resistant Staphylococcus aureus (MRSA) in the range of 61.25-250 µg/mL. Ceph-Au NPs are more active than Ceph-Ag NPs and can be used to treat the diseases associated with MRSA and S. mutans.

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Title: Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens
Creators - without role: Ajmal Khan - University of Nizwa
Humera Jabeen - Sardar Bahadur Khan Women's University
Touqeer Ahmad - University of Nizwa
Najeeb Ur Rehman - University of Nizwa
Saleha Suleman Khan - Sardar Bahadur Khan Women's University
Huma Shareef - Jinnah Sindh Medical University
Rizwana Sarwar - COMSATS University Islamabad
Saira Yahya - Shaheed Zulfiqar Ali Bhutto Institute of Science and Technology
Nusrat Hussain - University of Balochistan
Jalal Uddin - King Khalid University
Javid Hussain - University of Nizwa
Ahmed Al-Harrasi - University of Nizwa
Publication Details: Artificial cells, nanomedicine, and biotechnology, Vol.50(1), pp.312-321
Publisher: Taylor & Francis
Identifiers: 9922225408331
Academic Unit: King Khalid University
Language: English
Resource Type: Journal article