Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium

Li-Jun Ma; H. Charlotte van der Does; Katherine A. Borkovich; Jeffrey J. Coleman; Marie-Josee Daboussi; Antonio Di Pietro; Marie Dufresne; Michael Freitag; Manfred Grabherr; Bernard Henrissat; Petra M. Houterman; Seogchan Kang; Won-Bo Shim; Charles Woloshuk; Xiaohui Xie; Jin-Rong Xu; John Antoniw; Scott E. Baker; Burton H. Bluhm; Andrew Breakspear; Daren W. Brown; Robert A. E. Butchko; Sinead Chapman; Richard Coulson; Pedro M. Coutinho; Etienne G. J. Danchin; Andrew Diener; Liane R. Gale; Donald M. Gardiner; Stephen Goff; Kim E. Hammond-Kosack; Karen Hilburn; Aurelie Hua-Van; Wilfried Jonkers; Kemal Kazan; Chinnappa D. Kodira; Michael Koehrsen; Lokesh Kumar; Yong-Hwan Lee; Liande Li; John M. Manners; Diego Miranda-Saavedra; Mala Mukherjee; Gyungsoon Park; Jongsun Park; Sook-Young Park; Robert H. Proctor; Aviv Regev; M. Carmen Ruiz-Roldan; Divya Sain; Sharadha Sakthikumar; Sean Sykes; David C. Schwartz; B. Gillian Turgeon; Ilan Wapinski; Olen Yoder; Sarah Young; Qiandong Zeng; Shiguo Zhou; James Galagan; Christina A. Cuomo; H. Corby Kistler; Martijn Rep; Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

doi:10.1038/nature08850

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Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium

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Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium

Li-Jun Ma, H. Charlotte van der Does, Katherine A. Borkovich, Jeffrey J. Coleman, Marie-Josee Daboussi, Antonio Di Pietro, Marie Dufresne, Michael Freitag, Manfred Grabherr, Bernard Henrissat, …

Nature (London), Vol.464(7287), pp.367-373

18/03/2010

DOI: https://doi.org/10.1038/nature08850

PMCID: PMC3048781

PMID: 20237561

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Fusarium species are among the most important phytopathogenic and toxigenic fungi. To understand the molecular underpinnings of pathogenicity in the genus Fusarium, we compared the genomes of three phenotypically diverse species: Fusarium graminearum, Fusarium verticillioides and Fusarium oxysporum f. sp. lycopersici. Our analysis revealed lineage-specific (LS) genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome. LS regions are rich in transposons and genes with distinct evolutionary profiles but related to pathogenicity, indicative of horizontal acquisition. Experimentally, we demonstrate the transfer of two LS chromosomes between strains of F. oxysporum, converting a non-pathogenic strain into a pathogen. Transfer of LS chromosomes between otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F. oxysporum. These findings put the evolution of fungal pathogenicity into a new perspective.

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Title: Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium
Creators - without role: Li-Jun Ma - Broad Institute
H. Charlotte van der Does - University of Amsterdam
Katherine A. Borkovich - University of California, Riverside
Jeffrey J. Coleman - University of Arizona
Marie-Josee Daboussi - University of Paris-Sud
Antonio Di Pietro - University of Córdoba
Marie Dufresne - University of Paris-Sud
Michael Freitag - Oregon State University
Manfred Grabherr - Broad Institute
Bernard Henrissat - Aix-Marseille University
Petra M. Houterman - University of Amsterdam
Seogchan Kang - Pennsylvania State University
Won-Bo Shim - Texas A&M University
Charles Woloshuk - Purdue University West Lafayette
Xiaohui Xie - University of California, Irvine
Jin-Rong Xu - Purdue University West Lafayette
John Antoniw - Rothamsted Research
Scott E. Baker - Pacific Northwest National Laboratory
Burton H. Bluhm - Purdue University West Lafayette
Andrew Breakspear - University of Minnesota
Daren W. Brown - National Center for Agricultural Utilization Research
Robert A. E. Butchko - National Center for Agricultural Utilization Research
Sinead Chapman - Broad Institute
Richard Coulson - European Bioinformat Inst, Cambridge CB10 1SD, England
Pedro M. Coutinho - Aix-Marseille University
Etienne G. J. Danchin - Univ Aix Marseille, CNRS, F-13628 Aix En Provence, France
Andrew Diener - University of California, Los Angeles
Liane R. Gale - University of Minnesota
Donald M. Gardiner - Commonwealth Scientific and Industrial Research Organisation
Stephen Goff - University of Arizona
Kim E. Hammond-Kosack - Rothamsted Research
Karen Hilburn - University of Minnesota
Aurelie Hua-Van - University of Paris-Sud
Wilfried Jonkers - University of Amsterdam
Kemal Kazan - Commonwealth Scientific and Industrial Research Organisation
Chinnappa D. Kodira - Broad Institute
Michael Koehrsen - Broad Institute
Lokesh Kumar - Broad Institute
Yong-Hwan Lee - Seoul National University
Liande Li - University of California, Riverside
John M. Manners - Commonwealth Scientific and Industrial Research Organisation
Diego Miranda-Saavedra - College Station Medical Center
Mala Mukherjee - Texas A&M University
Gyungsoon Park - University of California, Riverside
Jongsun Park - Seoul National University
Sook-Young Park - Pennsylvania State University
Robert H. Proctor - USDA ARS NCAUR, Peoria, IL 61604 USA
Aviv Regev - Broad Institute
M. Carmen Ruiz-Roldan - Univ Cordoba, E-14071 Cordoba, Spain
Divya Sain - University of California, Riverside
Sharadha Sakthikumar - Broad Institute
Sean Sykes - Broad Institute
David C. Schwartz - University of Wisconsin–Madison
B. Gillian Turgeon - Cornell University
Ilan Wapinski - Broad Institute
Olen Yoder
Sarah Young - Broad Institute
Qiandong Zeng - Broad Institute
Shiguo Zhou - University of Wisconsin–Madison
James Galagan - Broad Institute
Christina A. Cuomo - Broad Institute
H. Corby Kistler - University of Minnesota
Martijn Rep - University of Amsterdam
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Publication Details: Nature (London), Vol.464(7287), pp.367-373
Publisher: Springer Nature
Number of pages: 7
Grant note: R01HG000225 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) DP1OD003958 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA BBS/E/C/00004973 / Biotechnology and Biological Sciences Research Council; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) R01GM086565 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) BBS/E/C/00004973 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) 2005-35600-16405 / USDA's National Institute of Food and Agriculture
Identifiers: 9936336608331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article