Abstract
This study linked the prognostic biomarkers to predict coronavirus disease 2019 (COVID‐19) disease severity, hence our decision to submit it to your journal. We aimed to compare COVID‐19 patients with and without complications regarding their clinical characteristics and laboratory findings and discriminate the important risk factors for the complications and death. This cross‐sectional study was carried out in a monocentric secondary healthcare hospital in Menoufia Governorate, Egypt, during the period between May 1st and June 31st, 2021. A convenient nonprobability sample of 75 patients, who were suspected clinically and confirmed by positive reverse transcription‐polymerase chain reaction as COVID‐19 cases, was recruited. Analysis of their clinical and laboratory information on admission including serum ferritin, thrombotic activity (
d
‐dimer), lactate dehydrogenase (LDH), C‐reactive protein (CRP), creatinine, aspartate aminotransferase, and alanine aminotransferase were done. Lymphocytopenia, tachycardia, tachypnea, elevated CRP,
d
‐dimer, serum ferritin, LDH, and decreased SP0
2
were significantly observed in cases with complicated severe acute respiratory syndrome coronavirus 2 (
p
< .05 for all). By using a multivariate logistic regression analysis model, elevated serum ferritin and tachycardia were significantly correlated with the increased odds of complicated COVID‐19 (odds ratio [confidence interval 95%] = 10.42 [2.32–46.89] and 8.01 [1.17–55.99], respectively) (
p
= .002 and .007; respectively). Lymphocytopenia,
d
‐dimer, LDH, and CRP levels, which were significantly linked to the severity of COVID‐19, were the prognostic biomarkers to predict the disease severity.