Abstract
Terminalia arjuna (Roxb.) Wight & Arn. is a herbal medicinal plant that is used in treatment of a large number of diseases, especially cardiac diseases along with common cardiovascular drugs like metoprolol, atorvastatin, enalapril maleate and aspirin. The aim of present study was to find out the safety of T. arjuna when co-administered with these drugs. Commercially available T. arjuna (Himalaya Herbal) was used for this studies. T. arjuna contains a number of active compounds that may have drug interaction. Based on parameters such as caking, liquefaction, odor, color and gel formation, no change was seen in the physical properties of T. arjuna alone and mixture of T. arjuna and cardiovascular drugs. The comparison of. max values of individual drugs and their mixture with T. arjuna revealed that there is no interaction of T. arjuna with these cardiovascular drugs. T. arjuna can therefore be used safely along with these drugs.