Abstract
Mixed-ligand complex formation equilibria of Pd(Me
2en)–CBDCA–DNA constituent have been investigated (Me
2en=
N,
N′-dimethylethylenediamine, CBDCA=cyclobutane dicarboxylic acid). The results show ring opening of CBDCA and monodentate complexation of the DNA constituent. Stoichiometries and stability constants of the complexes were determined at 25
°C and at constant 0.1 M ionic strength. The kinetics of base hydrolysis of glycine methyl ester in presence of Pd(Me
2en)
2+ complex was studied in aqueous solution at different temperatures, and in dioxane–water solutions of different compositions at 25
°C.
Mixed-ligand complex formation equilibria of Pd(Me
2en)–CBDCA–DNA constituent have been investigated. The results show ring opening of CBDCA and monodentate complexation of the DNA constituent. The mechanism of base hydrolysis of glycine methyl ester in presence of Pd(Me
2en)
2+ complex involves nucleophilic attack by external OH
− on the complexed ester group. The effects of temperature and dioxane on the hydrolysis were discussed.