Abstract
The goal of this paper is recognized to the chemical and microbial impact resulting from the interaction between nalidixic acid (NDX) and two lanthanide salts (GdCl3.6H(2)O and TbCl3.6H(2)O), which were prepared in normal and nano-scale range. Gadolinium and terbium(III) metal ions chelated with NDX through the deprotonation of carboxylic group of NDX bidentate ligand and oxygen atom of carbonyl group. The analytical analyses (elemental analyses, electrical conductivity) and spectroscopic measurements (FT-IR spectral, X-ray powder diffraction (XRD) and scanning electron microscopy (SEM)) as well as thermal analysis (TG/DTA) have been used to characterize the new solid complexes. The stability of NDX complexes was checked using Coats-Redfern and Horowitz-Metzger integral methods for the main thermal decomposition steps in the TG curves. The shiny side in this paper is focused on the preparation and characterization of single phases of gadolinium and terbium(III) oxide nanoparticles using carbamide as precursors. The NDX ligand in comparison with both cases traditional and nano-particles lanthanide complexes were assessment against for some kind of bacteria (Escherichia Coli, Staphylococcus Aureus, Bacillus subtilis and Pseudomonas aeruginosa) and fungi (Aspergillus Flavus and Candida Albicans) activities. The highest antibacterial and antifungal activities data of the nano-particles complexes were observed with more potent than the free NDX and traditional lanthanide complexes.