Abstract
The availability of chemical and biological data presented in this paper is the basis for understanding not only the current state of anti-cancer drugs based on gold( III ) but also the rationale for strategies for future drug design. New Au(III ) nanosized complexes of cefotaxime (ceph-3) and cefepime (ceph-4) ligands as a 3rd and 4th of cephalosporin generation drugs were synthesized. Gold( III ) complexes were discussed based on the elemental, molar conductance, thermal and magnetic moment measurements as well as spectral ( FTIR, (HNMR)-H-1, UV-Vis, and XRD) techniques. FT-IR spectra revealed that the ceph-3 and ceph-4 ligands reacted as a bidentate ligands through carboxylate oxygen and beta-lactam oxygen groups. The analytical analysis confirm that the molar ratio is 1 : 1 (Au+/ceph) with general formula [Au(L) (Cl)(2)] where L= ceph-3 or ceph-4. The structures of Au( III ) complexes were presence as a square planar geometry. X-ray diffraction patterns referred to a crystalline nature for all synthesized complexes. TEM analyses confirmed that the synthetic gold ( III ) complexes have a nanosized particles. In vitro antimicrobial activities of Au( Up complexes were evaluated towards two types of bacteria (G+ & G-). The antitumor activities of gold( III) complexes are appraised against breast (MCF-7) and colorectal adenocarcinoma (Caco-2) cell lines, which means that the two complexes may consider promising anticancer drugs.