Abstract
Background: Electrospinning is a modest and real tactic to harvest nanofiber membranes from micrometers to nanometers scale diameters, are useful in modern nanotechnology like biomedical, filtration, defense, catalysis, sensor and energy applications. Wound healing practice is deliberated a constant morphological modification of cells with the alteration of cell exodus, adherence, etc. In this characteristic, the advance of polymeric nanofiber scaffolds with together biodegradable and electrically conducting properties would be pronounced benefits in the biomedical field. Here it has been established the conducting polymer and biopolymer based electrospun nanofiber membranes exploited on wound healing and wound-size decline in rats successfully.
Methods: Ultrafine conducting polyaniline with o-aminobenzenesulfonic acid copolymer (PAni-co-PABSA) and poly (vinyl alcohol) (PVA)/chitosan oligossacaride (COS) biopolymers based electrospun nanofiber membranes have been exploited for wound healing applications. The nanofiber membranes were assembled by spawning double full-thickness skin wounds on the dorsum of SD rats.
Results: The current study is commenced to appraise the potentials for use of PAni-co-PABSA/PVA/COS electrospun nanofibers in wound healing in rats. The nanofiber membranes cured wounds show considerable lesser provocative responses throughout the experimental period. Area of nanofiber membranes and commercial (Fucidin (R)) ointment treated wounds are significantly decreased equate to control cured wounds. After 15 days treatment, the histological appearance by nanofiber membranes reveal almost complete healing and intensification in collagen and granulation as compare to control one.
Conclusion: The nanofiber membranes cured wounds have ample reduced inflammatory responses throughout the experimental period. Histological appearance after two weeks of management with PAni-co-PABSA/PVA/COS nanofiber reveals almost complete healing and an increase in collagen and granulation as compare to control.