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Construction of Esters through Sulfuryl Fluoride (SO (2) F (2) ) Mediated Dehydrative Coupling of Carboxylic Acids with Alcohols at Room Temperature
Journal article   Peer reviewed

Construction of Esters through Sulfuryl Fluoride (SO (2) F (2) ) Mediated Dehydrative Coupling of Carboxylic Acids with Alcohols at Room Temperature

Shi-Meng Wang, Njud S. Alharbi and Hua-Li Qin
Synthesis (Stuttgart), Vol.51(20), pp.3901-3907
15/10/2019
DOI: https://doi.org/10.1055/s-0039-1690017

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A facile method for the construction of esters through dehydrative coupling of carboxylic acids with alcohols is developed. The reactions are mediated by sulfuryl fluoride (SO (2) F (2) ) at room temperature and proceed with high efficiency. The method has several advantages including broad substrate scope, mild conditions, excellent functional group compatibility and affords high yields, even on gram scale.

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