Abstract
▶ Template technique was used to obtain well ordered nanostructured materials: SBA-15 and titania tubes. ▶ Phenytoin (PH), a drug used in epilepsy treatment, was loaded in these materials to used como PH release. ▶ Loaded PH showed a good stability inside the used materials as observed by spectroscopy analysis. ▶ The load-release PH are faster in nanostructured TiO2 tubes than in mesoporous silica matrix. ▶ There is an inverse effect of the surface area of the structured materials on the amount of released PH.
Template technique was used to obtain well ordered nanostructured materials: mesoporous silica and nanostructured titania tubes. This technique permits the synthesis of solids with controlled mesoporosity, where a large variety of molecules that have therapeutic activity can be hosted and further released to specific sites. In this work phenytoin (PH), a drug used in epilepsy treatment, was loaded in ordered mesoporous silica (SBA 15) and nanostructured titania tubes (TiO
2). The pure materials and those containing PH were characterized by X-ray diffraction, FTIR spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and N
2 adsorption–desorption at 77
K. In order to determine the loading capacity of the antiepileptic drug on these silica- and titania-based materials, the loading and release of PH was investigated using UV–vis spectroscopy. Tubular structures were found for the titania samples, for which the X-ray diffractograms showed to be formed by anatase and rutile phases. On the other hand, an amorphous phase was found in the silica sample. A highly ordered hexagonal structure of 1D cylindrical channels was also observed for this material. Loaded PH showed a good stability inside the used materials as observed by spectroscopy analysis. The adsorption and desorption of PH are faster in nanostructured TiO
2 tubes than in mesoporous silica matrix.