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Controlling epileptiform activity with organic electronic ion pumps
Journal article   Peer reviewed

Controlling epileptiform activity with organic electronic ion pumps

Adam Williamson, Jonathan Rivnay, Loïg Kergoat, Amanda Jonsson, Sahika Inal, Ilke Uguz, Marc Ferro, Anton Ivanov, Theresia Arbring Sjöström, Daniel T Simon, …
Advanced materials (Weinheim), Vol.27(20), pp.3138-3144
27/05/2015
DOI: https://doi.org/10.1002/adma.201500482
PMID: 25866154

Abstract

Action Potentials - drug effects Action Potentials - physiology Animals Anticonvulsants - administration & dosage CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - physiopathology CA3 Region, Hippocampal - drug effects CA3 Region, Hippocampal - physiopathology Chlorates - metabolism Electrical Equipment and Supplies Electrons Epilepsy - physiopathology Epilepsy - therapy Equipment Design gamma-Aminobutyric Acid - administration & dosage Ions - administration & dosage Magnesium - metabolism Mice Pyramidal Cells - drug effects Pyramidal Cells - physiology Tissue Culture Techniques
In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

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