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Convenient synthesis of Ibuprofen and naproxen aminoacyl, dipeptidoyl and ester derivatives
Journal article   Peer reviewed

Convenient synthesis of Ibuprofen and naproxen aminoacyl, dipeptidoyl and ester derivatives

Alan R Katritzky, Davit Jishkariani and Tamari Narindoshvili
Chemical biology & drug design, Vol.73(6), pp.618-626
06/2009
DOI: https://doi.org/10.1111/j.1747-0285.2009.00811.x
PMID: 19635053

Abstract

Amino Acids - chemistry Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Dipeptides - chemistry Esters Ibuprofen - analogs & derivatives Ibuprofen - chemical synthesis Ibuprofen - chemistry Naproxen - analogs & derivatives Naproxen - chemical synthesis Naproxen - chemistry Prodrugs - chemical synthesis Prodrugs - chemistry Stigmasterol - chemistry
DL-Ibuprofen and L-naproxen were coupled with amino acids and other bioactive compounds to provide ibuprofen and naproxen bioconjugates in 61-95% yield as prodrugs or potential drug candidates.

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