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Convenient synthesis of substituted pyrroles via a cerium (IV) ammonium nitrate (CAN)-catalyzed Paal–Knorr reaction
Journal article   Open access  Peer reviewed

Convenient synthesis of substituted pyrroles via a cerium (IV) ammonium nitrate (CAN)-catalyzed Paal–Knorr reaction

Ahmed Kamal, Shaikh Faazil, M. Shaheer Malik, Moku Balakrishna, Shaik Bajee, M. Rafique H. Siddiqui, Abdullah Alarifi and M. Shaheer Malik
Arabian journal of chemistry, Vol.9(4), pp.542-549
07/2016
DOI: https://doi.org/10.1016/j.arabjc.2013.04.009

Abstract

2,5-Dimethoxy-tetrahydrofuran CAN Cerium (IV) ammonium nitrate Paal–Knorr reaction Pyrrole γ-Diketone
A screening of various cerium salts for promoting the Paal–Knorr pyrrole synthesis revealed the superiority of cerium (IV) ammonium nitrate (CAN) as a catalyst. Excellent yields of substituted pyrroles were obtained in CAN-catalyzed Paal–Knorr reactions of 1,4-diketones with various amines. The protocol is noteworthy for the mild reaction condition, short reaction times, scalability and easy isolation of products and high yields of the products.
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https://doi.org/10.1016/j.arabjc.2013.04.009View
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