Abstract
In this paper, determination of memantine hydrochloride using comparative potentiometric study was developed and validated. The proposed method based on the construction of five types of memantine sensors. A plastic membrane type (I), coated wire type (II), coated graphite type (III), carbon paste type (IV) and modified carbon nanotubes paste type (V). The electroactive materials such as phosphotungstic acid (PTA), tungstosilicic acid (TSA), sodium tetraphenyl borate (TPB) and ammonium reineckate salt (ARS) were used for the fabrication of the proposed sensors. The fabricated sensors were based on the incorporation of memantine hydrochloride with phosphotungstic acid, tungstosilicic acid, and sodium tetraphenyl borate forming memantine-phosphotungstate, memantine-tugstosilicate, and memantine-tetraphenylborate as electroactive materials for sensors I, II and III, respectively. While, memantine-reineckate was used for sensors IV and V. The performance characteristics of the fabricated sensors was investigated and evaluated. The proposed sensors showed Nernstian response (55.9 +/- 0.2, 54.2 +/- 0.5, 53.3 +/- 0.1, 56.2 +/- 0.8 and 57.8 +/- 0.4 mV decade(-1)) over linear concentration ranges of (1.0 x 10(-6)-1.0 x 10(-2), 1.0 x 10(-6)-1.0 x 10(-2), 5.0 x 10(-6)-5.0 x 10(-3), 9.7 x 10(-7)-1.0 x 10(-2) and 1.0 x 10(-7)-1.0 x 10(-1) mol L-1) with limits of detection 5.0 x 10(-7), 4.6 x 10(-7), 2.5 x 10(-6), 3.9 x 10(-7) and 5.0 x 10(-8) mol L-1 for sensors I, II, III, IV and V, respectively. The influence of common and possible interfering species or pharmaceutical additives was studied. No interference was found. The results of the fabricated sensors were validated statistically by recovery studies and the proposed method has been successfully applied for the analysis of memantine hydrochloride in pure form and its commercial tablets.