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Copper-Catalyzed Hydroamination of Alkynes with Aliphatic Amines: Regioselective Access to (1E,3E)-1,4-Disubstituted-1,3-dienes
Journal article   Peer reviewed

Copper-Catalyzed Hydroamination of Alkynes with Aliphatic Amines: Regioselective Access to (1E,3E)-1,4-Disubstituted-1,3-dienes

Janet Bahri, Bassem Jamoussi, Arie van Der Lee, Marc Taillefer and Florian Monnier
Organic letters, Vol.17(5), pp.1224-1227
06/03/2015
DOI: https://doi.org/10.1021/acs.orglett.5b00177
PMID: 25705988

Abstract

Chemical Sciences Organic chemistry
Copper-catalyzed hydroamination of aromatic or heteroaromatic alkynes with cyclic secondary aliphatic amines undergoes generation of an enamine-type intermediate. The latter is transformed in situ via a coupling reaction with a second molecule of alkyne to afford regioselectively (1E,3E)-1,4-disubstituted-1,3-dienes with the formation of C–N, C–C, and C–H bonds.

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