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Copper-mediated Chan-Evans-Lam N-arylation of 5-methylene-4-aryl1,5-dihydro-2H-pyrrol-2-one derivatives
Journal article   Peer reviewed

Copper-mediated Chan-Evans-Lam N-arylation of 5-methylene-4-aryl1,5-dihydro-2H-pyrrol-2-one derivatives

Basmah Almohaywi, George Iskander, Tsz Tin Yu, Mohan Bhadbhade, David St C. Black and Naresh Kumar
Tetrahedron letters, Vol.59(9), pp.811-814
28/02/2018
DOI: https://doi.org/10.1016/j.tetlet.2018.01.039

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A simple and efficient procedure for the synthesis of N-aryl 5-methylene-4-aryl-1,5-dihydro-2H-pyrrol2-one derivatives has been developed through copper-mediated C-N bond formation. The synthetic protocol allows for versatile and robust C-N arylation with a range of readily available boronic acids under mild conditions. (C) 2018 Elsevier Ltd. All rights reserved.

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