Abstract
The catalytic effect of copper(II) catalyst on the oxidation of L-tryptophan (Trp) by hexacyanoferrate(III) (HCF), has been investigated spectrophotometrically in an aqueous alkaline medium at a constant ionic strength of 0.5 mol dm(-3) and at 25 degrees C. The stoichiometry for both the uncatalyzed and catalyzed reactions was 1:2 (Trp:HCF). The reactions exhibited first order kinetics with respect to [HCF] and less than unit orders with respect to [Trp] and [OH-]. The catalyzed reaction exhibited fractional-first order kinetics with respect to [Cu-II]. The reaction rates were found to increase as the ionic strength and dielectric constant of the reaction medium increase. The effect of temperature on the rates of reactions has also been studied, and the activation parameters associated with the rate-determining steps of the reactions have been evaluated and discussed. Addition of the reaction product HCF(II) to the reaction mixture did not affect the rates. Plausible mechanistic schemes for uncatalyzed and catalyzed reactions explaining all of the observed kinetic results have been proposed. In both cases, the final oxidation products are identified as indole-3acetaldehyde, ammonia, and carbon dioxide. The rate laws associated with the reactions' mechanisms are derived. The rate constants of the slow steps of the reactions along with the equilibrium constants are also calculated. (C) 2015 King Saud University. Production and hosting by Elsevier B.V.