Abstract
Aim: To investigate the correlation between erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP) levels with systemic lupus erythematosus (SLE) disease activity index (SLEDAI) as well as the onset of renal impairment in inactive and active groups of SLE patients.
Methods: This study was done using 49 women patients who are positive for SLE. They were classified into inactive and active groups based on the SLEDAI. All the physical examination and the laboratory parameters were used to determine SLEDAI. Fully automated cell counter was used for the estimation of ESR and the CRP was detected by latex agglutination slide test.
Results: ESR was significant in SLEDAI inactive group and SLEDAI active group. There was no significant correlation between SLEDAI and CRP positive and negative patients. There was no significant difference between inactive and active groups with reference to red blood cells (RBC) and white blood cells (WBC) in urine.
Conclusion: The correlation levels found in this study can be used as an appropriate marker for evaluation of disease activity and also used as an onset for renal impairment for SLE patients.