Abstract
Advanced glycation end products (AGEs) are known to play a pivotal role in the development of diabetes and its complications. Adipocytokines are important mediators of inflammatory and immune responses. The aim of this study was to investigate the correlation between serum levels of adipocytokines and AGEs in diabetic and non-diabetic patients with myocardial infarction. In the present study, serum leptin, serum adiponectin, interleukin-6 (IL-6), IL-8, tumor necrosis factor-alpha (TNF-alpha) and serum AGEs were investigated. Human serum samples of normal older subjects (n = 31), diabetic patients without myocardial infarction (n = 33), older diabetic patients with myocardial infarction (n = 32) and older non-diabetic with myocardial infarction (n = 30) were investigated. The patients were selected on clinical grounds from the National Institute of Cardiovascular Disease and the Jinnah Postgraduate Medical Centre, Karachi, Pakistan. Values of leptin, IL-6, IL-8, TNF-alpha and serum AGEs were significantly increased (P < 0.001) in diabetic and non-diabetic patients with and without myocardial infarction as compared with older healthy control subjects. Values of adiponectin were significantly decreased (P < 0.001) in diabetic and non-diabetic patients with and without myocardial infarction as compared with older healthy control subjects. Positive significant correlation was found between fasting blood glucose and serum AGEs, body mass index (BMI) and TNF-alpha, BMI and leptin, IL-6 and leptin, and IL-6 and TNF-alpha in all groups. A significant positive correlation was observed between systolic blood pressure and serum AGEs in older diabetic and non-diabetic patients with or without myocardial infarction. Negative significant correlation was found between BMI and adiponectin and IL-6 and adiponectin in all groups. Taken together, these findings demonstrate adipocytokines and AGEs levels were correlated with myocardial infarction in diabetic and non-diabetic patients suggesting its key role in the mechanism that links myocardial infarction.