Crowd Sourcing a New Paradigm for Interactome Driven Drug Target Identification in Mycobacterium tuberculosis

Rohit Vashisht; Anupam Kumar Mondal; Akanksha Jain; Anup Shah; Priti Vishnoi; Priyanka Priyadarshini; Kausik Bhattacharyya; Harsha Rohira; Ashwini G. Bhat; Anurag Passi; Keya Mukherjee; Kumari Sonal Choudhary; Vikas Kumar; Anshula Arora; Prabhakaran Munusamy; Ahalyaa Subramanian; Aparna Venkatachalam; S. Gayathri; Sweety Raj; Vijaya Chitra; Kaveri Verma; Salman Zaheer; J. Balaganesh; Malarvizhi Gurusamy; Mohammed Razeeth; Ilamathi Raja; Madhumohan Thandapani; Vishal Mevada; Raviraj Soni; Shruti Rana; Girish Muthagadhalli Ramanna; Swetha Raghavan; Sunil N. Subramanya; Trupti Kholia; Rajesh Patel; Varsha Bhavnani; Lakavath Chiranjeevi; Soumi Sengupta; Pankaj Kumar Singh; Naresh Atray; Swati Gandhi; Tiruvayipati Suma Avasthi; Shefin Nisthar; Meenakshi Anurag; Pratibha Sharma; Yasha Hasija; Debasis Dash; Arun Sharma; Vinod Scaria; Zakir Thomas; Nagasuma Chandra; Samir K. Brahmachari; Anshu Bhardwaj; OSDD Consortium

doi:10.1371/journal.pone.0039808

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Crowd Sourcing a New Paradigm for Interactome Driven Drug Target Identification in Mycobacterium tuberculosis

Journal article

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Crowd Sourcing a New Paradigm for Interactome Driven Drug Target Identification in Mycobacterium tuberculosis

Rohit Vashisht, Anupam Kumar Mondal, Akanksha Jain, Anup Shah, Priti Vishnoi, Priyanka Priyadarshini, Kausik Bhattacharyya, Harsha Rohira, Ashwini G. Bhat, Anurag Passi, …

PloS one, Vol.7(7), pp.e39808-e39808

11/07/2012

DOI: https://doi.org/10.1371/journal.pone.0039808

PMCID: PMC3395720

PMID: 22808064

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

A decade since the availability of Mycobacterium tuberculosis (Mtb) genome sequence, no promising drug has seen the light of the day. This not only indicates the challenges in discovering new drugs but also suggests a gap in our current understanding of Mtb biology. We attempt to bridge this gap by carrying out extensive re-annotation and constructing a systems level protein interaction map of Mtb with an objective of finding novel drug target candidates. Towards this, we synergized crowd sourcing and social networking methods through an initiative 'Connect to Decode' (C2D) to generate the first and largest manually curated interactome of Mtb termed '3interactome pathway' (IPW), encompassing a total of 1434 proteins connected through 2575 functional relationships. Interactions leading to gene regulation, signal transduction, metabolism, structural complex formation have been catalogued. In the process, we have functionally annotated 87% of the Mtb genome in context of gene products. We further combine IPW with STRING based network to report central proteins, which may be assessed as potential drug targets for development of drugs with least possible side effects. The fact that five of the 17 predicted drug targets are already experimentally validated either genetically or biochemically lends credence to our unique approach.

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Title: Crowd Sourcing a New Paradigm for Interactome Driven Drug Target Identification in Mycobacterium tuberculosis
Creators - without role: Rohit Vashisht - Indian Institute of Science Bangalore
Anupam Kumar Mondal - Council of Scientific and Industrial Research
Akanksha Jain - Council of Scientific and Industrial Research
Anup Shah - Council of Scientific and Industrial Research
Priti Vishnoi - Council of Scientific and Industrial Research
Priyanka Priyadarshini - Council of Scientific and Industrial Research
Kausik Bhattacharyya - Council of Scientific and Industrial Research
Harsha Rohira - University of Delhi
Ashwini G. Bhat - Indian Institute of Science Bangalore
Anurag Passi - Council of Scientific and Industrial Research
Keya Mukherjee - Council of Scientific and Industrial Research
Kumari Sonal Choudhary - Council of Scientific and Industrial Research
Vikas Kumar - Goethe University Frankfurt
Anshula Arora - University of Delhi
Prabhakaran Munusamy - PSG Coll Technol, Coimbatore, Tamil Nadu, India
Ahalyaa Subramanian - SASTRA University
Aparna Venkatachalam - SASTRA University
S. Gayathri - SDM Coll, Ujire, Karnataka, India
Sweety Raj - University of Delhi
Vijaya Chitra - Sree Narayan Guru Coll, Coimbatore, Tamil Nadu, India
Kaveri Verma - Maharshi Dayanand University
Salman Zaheer - Amity Univ, Amity Inst Biotechnol, Lucknow, Uttar Pradesh, India
J. Balaganesh - Bharathiar University
Malarvizhi Gurusamy - Bharathidasan University
Mohammed Razeeth - Bharathidasan University
Ilamathi Raja - Bharathidasan University
Madhumohan Thandapani - Bharathidasan University
Vishal Mevada - Gujarat University
Raviraj Soni - Gujarat University
Shruti Rana - Gujarat University
Girish Muthagadhalli Ramanna - Business Intelligence Technol India Pvt Ltd, Bangalore, Karnataka, India
Swetha Raghavan - Business Intelligence Technol India Pvt Ltd, Bangalore, Karnataka, India
Sunil N. Subramanya - Business Intelligence Technol India Pvt Ltd, Bangalore, Karnataka, India
Trupti Kholia - Saurashtra University
Rajesh Patel - Hemchandracharya North Gujarat University
Varsha Bhavnani - Savitribai Phule Pune University
Lakavath Chiranjeevi - Indian Institute of Toxicology Research
Soumi Sengupta - Indian Statistical Institute
Pankaj Kumar Singh - Maulana Azad National Institute of Technology
Naresh Atray - Shri Ram Coll Pharm, Karnal, Haryana, India
Swati Gandhi - Maharaj Sayajirao Univ Baroda, Baroda, Gujarat, India
Tiruvayipati Suma Avasthi - University of Malaya
Shefin Nisthar - University of Kerala
Meenakshi Anurag - Council of Scientific and Industrial Research
Pratibha Sharma - All India Institute of Medical Sciences
Yasha Hasija - Delhi Technological University
Debasis Dash - Council of Scientific and Industrial Research
Arun Sharma - Council of Scientific and Industrial Research
Vinod Scaria - Council of Scientific and Industrial Research
Zakir Thomas - Council of Scientific and Industrial Research
Nagasuma Chandra - Indian Institute of Science Bangalore
Samir K. Brahmachari - Council of Scientific and Industrial Research
Anshu Bhardwaj - Council of Scientific and Industrial Research
OSDD Consortium
Publication Details: PloS one, Vol.7(7), pp.e39808-e39808
Publisher: Public Library Science
Number of pages: 11
Grant note: HCP0001 / Council of Scientific and Industrial Research, India; Council of Scientific & Industrial Research (CSIR) - India Hewlett-Packard Sun Microsystems
Identifiers: 9934478808331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article